On America's frontier, a St. Louis woman marries a New Mexico cattleman who is seen as a tyrant by the locals.
Duke Fergus falls for Ann 'Flaxen' Tarry in the Barbary Coast in turn-of-the-century San Francisco. He loses money to crooked gambler Boss Tito Morell, goes home, learns to gamble, and returns. After he makes a fortune, he opens his own place with Flaxen as the entertainer; but the 1906 quake destroys his place.
Hoppy, California and Johnny partner up with brother and sister ranch owners, two of several who are having their access to water blocked by a dam owned by a greedy merchant in town, who is intent on driving them out and taking their land for himself.
When Jesse learns that Krager is cheating settlers, he and his gang rob trains to obtain money for them to purchase their land. Krager, finding a Jesse look alike in Burns, hires him to wreck havoc on the ranchers. When Jesse kills Burns he switches clothes and goes after the culprits.
Egbert Sousé becomes an unexpected hero when a bank robber falls over a bench he's occupying. Now considered brave, Egbert is given a job as a bank guard. Soon, he is approached by charlatan J. Frothingham Waterbury about buying shares in a mining company. Egbert persuades teller Og Oggilby to lend him bank money, to be returned when the scheme pays off. Unfortunately, bank inspector Snoopington then makes a surprise appearance.
Viennese surgeon Dr. Braun and his daughter Leni come to a small town in North Dakota as refugees from Hitler. When the winds of the Dust Bowl threaten the town, John Phillips leads the townsfolk in moving to greener pastures in Oregon. He falls for Leni, but she is betrothed to the man who helped her and her father escape from the Third Reich. She must decide between the two men.
While on her way by stagecoach to visit relatives out west, Flower Belle Lee is held up by a masked bandit who also takes the coach's shipment of gold. When he abducts Flower Belle and they arrive in town, Flower Belle is suspected of being in collusion with the bandit.
Fields plays "Larsen E. Whipsnade", the owner of a shady carnival that is constantly on the run from the law. Whipsnade is struggling to keep a step ahead of foreclosure, and clearly not paying his performers, including Bergen and McCarthy, who try to coax money out of him, or in McCarthy's case, steal some outright.
Roscoe the Rainmaker is invited to California (with sidekick "Billy") to relieve a terrible dry spell and to save the community from an unscrupulous businessman who stands to profit from the drought