When loser Duke, who has screwed up every hair-brained scheme he's ever come up with, accidentally falls off a cruise ship and wakes up on a mysteriously abandoned, top secret government island, he discovers that it's overrun with mutants and monsters from a failed 1980s DARPA "super soldier" project to stop the 2nd Cold War.
An unmitigated and sexy conman targets his next mark, the widowed Monique, for his latest swindle. But his routine scam hits a snag when suspicion mounts and his scheme quickly escalate into desperation, betrayal and murder.