Gru and Lucy and their girls—Margo, Edith and Agnes—welcome a new member to the Gru family, Gru Jr., who is intent on tormenting his dad. Gru also faces a new nemesis in Maxime Le Mal and his femme fatale girlfriend Valentina, forcing the family to go on the run.
Former FBI Agent Will Graham, who was once almost killed by the savage Hannibal 'The Cannibal' Lecter, now has no choice but to face him again, as it seems Lecter is the only one who can help Graham track down a new serial killer.
Siblings Wednesday and Pugsley Addams will stop at nothing to get rid of Pubert, the new baby boy adored by parents Gomez and Morticia. Things go from bad to worse when the new "black widow" nanny, Debbie Jellinsky, launches her plan to add Fester to her collection of dead husbands.