A military experiment conducted on a space station goes horribly wrong, sending a new breed of weaponized sharks to earth with only one mission: destroy everything in their path.
Something is causing the rattlesnakes in Southern California to mutate to enormous sizes, and it’s up to Dr. Kaye to stop their growth before they destroy Los Angeles.
Just when you thought it couldn't get any worse, the Arachnado has returned, this time as a "Firenado" with Flaming Spiders. It's up to a renegade Sergeant Preston and the Janitor from the original film to overthrow the corrupt Lieutenant Gallagher and put the fire out.