A group of hip friends gather at a Gothic castle owned by a wheelchair- bound older relative of one of the girls. One couple in the group, unbeknownst to the others, is smuggling heroin in some Chinese artifacts the protagonist has brought back from the Orient to give to her elderly relative. Meanwhile the deranged uncle of the protagonist, who supposedly killed the protagonist's mother (his own sister) and cut out her eyes, is wandering the catacombs spying on everyone. When one of the guests is murdered and her eyes subsequently disappear, suspicion naturally falls on the mad uncle. But is he being set up?
The story of fish-monger Nino of Rione Borgo. Nino is in love with Rosa but he always manages to postpone their wedding.
Django comes to town to discover that his brother Steve, accused of robbing a bank, has been lynched. Django believes the real culprit is Sartana and challenges him to a duel. Just in time he discovers that the author of the crime is an important local figure and Django and Sartana join forces to punish him.