In the mid-19th century, California, a Mexican territory, became part of the United States. Faced with the possibility of being dispossessed of his land by the new authorities, Don César de Echagüe, a Spanish nobleman, asks his son César, a capricious and insufferable fop, for help.
Diana and Deric have an ideal marriage: they thrive in each other's company, they're funny, and they enjoy their two grown children and Deric's dotty mother; the trouble is, Diana can no longer walk and her malady defies medical diagnosis. To care for Diana, Deric is letting his business slide, but at a civic luncheon, he is seated next to Aileen Armitage, a novelist who is blind. They have a nice time, and on the sly, Diana contacts Aileen to made an odd request. Diana's declining health and her resolve bring this triangle of unlikely friends to a surprising place.
An elderly woman learns that she is dying of cancer. She and her husband leave their small farm on the Isle of Skye to visit their children to inform them of the news. During the journey, the couple rediscover their love for each other.
Needle paints a harrowing picture of a Liverpool overrun by drugs, charting a young man's nightmarish descent into intravenous heroin use and AIDS and a police and political leadership incapable of the imagination or courage necessary to respond to the drug problem.